Non-traditional Relationship between Carotid Intima-media Thickness and Mean Platelet Volume, Serum Magnesium and 25-OH-Vitamin D3 Level in Chronic Kidney Disease

Aım: Cardiovascular diseases are the most important causes of mortality and morbidity in chronic renal disease. The purpose of this study is to determine the relationship between glomerular filtration rate, serum levels of calcium, phosphorus, magnesium parathormone, vitamin D, lipids and hematological parameters and carotid intima-media thickness (CIMT) in chronic renal patients and healthy indiviuals.

Methods: Twenty-seven healthy individuals [(control group (CG)] and 53 patients with chronic renal failure (CRF) (GFR 15-59 ml/min) [study group (SG)] were included in this case control study. All participants’ characteristics, physical examination and laboratory tests results were recorded. Same radiologist measured bilateral CIMT by color Doppler ultrasonography.

Results: CG and SG were similar for age, gender. Besides CIMT was higher in patients with chronic renal failure, CIMT were correlated with systolic blood pressure (SBP), platelet, magnesium, alkaline phosphatase (ALP), parathormone (PTH) positively, 25-OH vitamin D3, high density lipoprotein (HDL) negatively. In CG CIMT was positively correlated with SBP, body mass index (BMI), serum levels of albumin, glucose, ALP, and mean platelet volume (MPV).

Conclusion: CIMT was higher in patients with CRF compared to healthy controls. Besides the serum levels of glucose, albumin, HDL, and BMI, CIMT were correlated with non-traditional factors such as higher serum magnesium and PTH level, 25-OH vitamin D3 deficiency in patients with chronic renal failure.